Hypoxic human proximal tubular epithelial cells undergo ferroptosis and elicit an NLRP3 inflammasome response in CD1c + dendritic cells

by Giuliani, Kurt T K, Grivei, Anca, Nag, Purba, Wang, Xiangju, Rist, Melissa, Kildey, Katrina, Law, Becker, Ng, Monica S, Wilkinson, Ray, Ungerer, Jacobus, Forbes, Josephine M, Healy, Helen, Kassianos, Andrew J
Published in Cell death & disease

Development of CAR-T cells specifically targeting cancer stem cell antigen DNAJB8 against solid tumours

by Watanabe, Yuto, Tsukahara, Tomohide, Murata, Kenji, Hamada, Shuto, Kubo, Terufumi, Kanaseki, Takayuki, Hirohashi, Yoshihiko, Emori, Makoto, Teramoto, Atsushi, Nakatsugawa, Munehide, Yamashita, Toshihiko, Torigoe, Toshihiko
Published in British journal of cancer

Favipiravir Use in COVID-19: Analysis of Suspected Adverse Drug Events Reported in the WHO Database

by Kaur, Rimple Jeet, Charan, Jaykaran, Dutta, Siddhartha, Sharma, Paras, Bhardwaj, Pankaj, Sharma, Praveen, Lugova, Halyna, Krishnapillai, Ambigga, Islam, Salequl, Haque, Mainul, Misra, Sanjeev
Published in Infection and drug resistance

Biological drug and drug delivery-mediated immunotherapy

by Xiao, Qingqing, Li, Xiaotong, Li, Yi, Wu, Zhenfeng, Xu, Chenjie, Chen, Zhongjian, He, Wei
Published in Acta pharmaceutica Sinica. B

Neurological manifestations of long-COVID syndrome: a narrative review

by Stefanou, Maria-Ioanna, Palaiodimou, Lina, Bakola, Eleni, Smyrnis, Nikolaos, Papadopoulou, Marianna, Paraskevas, George P., Rizos, Emmanouil, Boutati, Eleni, Grigoriadis, Nikolaos, Krogias, Christos, Giannopoulos, Sotirios, Tsiodras, Sotirios, Gaga, Mina, Tsivgoulis, Georgios
Published in Therapeutic Advances in Chronic Disease

Application of In vitro transcytosis models to brain targeted biologics

by Deng, Kangwen, Lu, Yifeng, Finnema, Sjoerd J, Vangjeli, Kostika, Huang, Junwei, Huang, Lili, Goodearl, Andrew
Published in PloS one

EANO guideline on rational molecular testing of gliomas, glioneuronal, and neuronal tumors in adults for targeted therapy selection

by Capper, David, Reifenberger, Guido, French, Pim J, Schweizer, Leonille, Weller, Michael, Touat, Mehdi, Niclou, Simone P, Euskirchen, Philipp, Haberler, Christine, Hegi, Monika E, Brandner, Sebastian, Le Rhun, Emilie, Rudà, Roberta, Sanson, Marc, Tabatabai, Ghazaleh, Sahm, Felix, Wen, Patrick Y, Wesseling, Pieter, Preusser, Matthias, van den Bent, Martin J
Published in Neuro-oncology (Charlottesville, Va.)

Updated report on tools to measure outcomes of clinical trials in fragile X syndrome

by Budimirovic, Dejan B, Berry-Kravis, Elizabeth, Erickson, Craig A, Hall, Scott S, Hessl, David, Reiss, Allan L, King, Margaret K, Abbeduto, Leonard, Kaufmann, Walter E
Published in Journal of neurodevelopmental disorders

PROTAC therapy as a new targeted therapy for lung cancer

by Li, Jennifer W., Zheng, Guangrong, Kaye, Frederic J., Wu, Lizi
Published in Molecular therapy

Vaccines to prevent COVID-19: a protocol for a living systematic review with network meta-analysis including individual patient data (The LIVING VACCINE Project)

by Korang, Steven Kwasi, Juul, Sophie, Nielsen, Emil Eik, Feinberg, Joshua, Siddiqui, Faiza, Ong, Giok, Klingenberg, Sarah, Veroniki, Areti Angeliki, Bu, Fanlong, Thabane, Lehana, Thomsen, Allan Randrup, Jakobsen, Janus C, Gluud, Christian
Published in Systematic reviews

Increased variability in Greenland Ice Sheet runoff from satellite observations

by Slater, Thomas, Shepherd, Andrew, McMillan, Malcolm, Leeson, Amber, Gilbert, Lin, Muir, Alan, Munneke, Peter Kuipers, Noël, Brice, Fettweis, Xavier, van den Broeke, Michiel, Briggs, Kate
Published in Nature communications

Vector Affinity and Receptor Distribution Define Tissue-Specific Targeting in an Engineered AAV Capsid

by Martino, R Alexander, Wang, Qiang, Xu, Hao, Hu, Gui, Bell, Peter, Arroyo, Edgardo J, Sims, Joshua J, Wilson, James M
Published in Journal of virology

Computational modeling and synthesis of pyridine variants of benzoyl-phenoxy-acetamide with high glioblastoma cytotoxicity and brain tumor penetration

by Ingraham, 4th, Charles H, Stalinska, Joanna, Carson, Sean C, Colley, Susan B, Rak, Monika, Lassak, Adam, Peruzzi, Francesca, Reiss, Krzysztof, Jursic, Branko S
Published in Scientific reports

PTK2-associated gene signature could predict the prognosis of IPF

by Feng, Anlin, Caro, Yesenia Moreno, Gardner, Colin, Grischo, Garrett, Liang, Ying, Wickremasinghe, Praveen D, Polmann, Michaela, Kala, Mrinalini, Marlowe, Timothy, Black, Stephen M, Knox, Kenneth S, Wang, Ting
Published in Respiratory research

Pixelated Microfluidics for Drug Screening on Tumour Spheroids and Ex Vivo Microdissected Tumour Explants

by Dorrigiv, Dina, Goyette, Pierre-Alexandre, St-Georges-Robillard, Amélie, Mes-Masson, Anne-Marie, Gervais, Thomas
Published in Cancers

Structure-based design of nanobodies that inhibit seeding of Alzheimer's patient-extracted tau fibrils

by Abskharon, Romany, Pan, Hope, Sawaya, Michael R, Seidler, Paul M, Olivares, Eileen J, Chen, Yu, Murray, Kevin A, Zhang, Jeffrey, Lantz, Carter, Bentzel, Megan, Boyer, David R, Cascio, Duilio, Nguyen, Binh A, Hou, Ke, Cheng, Xinyi, Pardon, Els, Williams, Christopher K, Nana, Alissa L, Vinters, Harry V, Spina, Salvatore, Grinberg, Lea T, Seeley, William W, Steyaert, Jan, Glabe, Charles G, Ogorzalek Loo, Rachel R, Loo, Joseph A, Eisenberg, David S
Published in Proceedings of the National Academy of Sciences - PNAS

A knowledge-guided pre-training framework for improving molecular representation learning

by Li, Han, Zhang, Ruotian, Min, Yaosen, Ma, Dacheng, Zhao, Dan, Zeng, Jianyang
Published in Nature communications

A universal fluorescence polarization high throughput screening assay to target the SAM-binding sites of SARS-CoV-2 and other viral methyltransferases

by Samrat, Subodh Kumar, Bashir, Qamar, Zhang, Ran, Huang, Yiding, Liu, Yuchen, Wu, Xiangmeng, Brown, Tyler, Wang, Wei, Zheng, Y. George, Zhang, Qing-Yu, Chen, Yin, Li, Zhong, Li, Hongmin
Published in Emerging microbes & infections

fingeRNAt-A novel tool for high-throughput analysis of nucleic acid-ligand interactions

by Szulc, Natalia A, Mackiewicz, Zuzanna, Bujnicki, Janusz M, Stefaniak, Filip
Published in PLoS computational biology

Understanding Payer Perspectives on Value in the Use of Pharmaceuticals in the United States

by Brogan, Andrew P., Hogue, Susan L., Vekaria, Renu M., Reynolds, Ian, Coukell, Allan
Published in Journal of managed care & specialty pharmacy