BH3 mimetics induce apoptosis independent of DRP-1 in melanoma

by Mukherjee, Nabanita, Strosnider, Andrew, Vagher, Bay, Lambert, Karoline A, Slaven, Sarah, Robinson, William A, Amato, Carol M, Couts, Kasey L, Bemis, Judson G T, Turner, Jacqueline A, Norris, David A, Shellman, Yiqun G
Published in Cell death & disease

Targeted protein degradation: mechanisms, strategies and application

by Zhao, Lin, Zhao, Jia, Zhong, Kunhong, Tong, Aiping, Jia, Da
Published in Signal transduction and targeted therapy

Recognition and reprogramming of E3 ubiquitin ligase surfaces by α-helical peptides

by Tokareva, Olena S, Li, Kunhua, Travaline, Tara L, Thomson, Ty M, Swiecicki, Jean-Marie, Moussa, Mahmoud, Ramirez, Jessica D, Litchman, Sean, Verdine, Gregory L, McGee, John H
Published in Nature communications

Comparison of safety and immunogenicity of CoronaVac and ChAdOx1 against the SARS-CoV-2 circulating variants of concern (Alpha, Delta, Beta) in Thai healthcare workers

by Angkasekwinai, Nasikarn, Sewatanon, Jaturong, Niyomnaitham, Suvimol, Phumiamorn, Supaporn, Sukapirom, Kasama, Sapsutthipas, Sompong, Sirijatuphat, Rujipas, Wittawatmongkol, Orasri, Senawong, Sansnee, Mahasirimongkol, Surakameth, Trisiriwanich, Sakalin, Chokephaibulkit, Kulkanya
Published in Vaccine: X

Multi-antigen-targeted chimeric antigen receptor T cells for cancer therapy

by Han, Xiao, Wang, Yao, Wei, Jianshu, Han, Weidong
Published in Journal of hematology and oncology

Selective delivery of low-affinity IL-2 to PD-1+ T cells rejuvenates antitumor immunity with reduced toxicity

by Ren, Zhenhua, Zhang, Anli, Sun, Zhichen, Liang, Yong, Ye, Jianfeng, Qiao, Jian, Li, Bo, Fu, Yang-Xin
Published in The Journal of clinical investigation

Progression analysis versus traditional methods to quantify slowing of disease progression in Alzheimer's disease

by Jönsson, Linus, Ivkovic, Milana, Atri, Alireza, Handels, Ron, Gustavsson, Anders, Hahn-Pedersen, Julie Hviid, León, Teresa, Lilja, Mathias, Gundgaard, Jens, Raket, Lars Lau
Published in Alzheimer's research & therapy

Drug-target affinity prediction with extended graph learning-convolutional networks

by Qi, Haiou, Yu, Ting, Yu, Wenwen, Liu, Chenxi
Published in BMC bioinformatics

Exploring new uses for existing drugs: innovative mechanisms to fund independent clinical research

by Verbaanderd, Ciska, Rooman, Ilse, Huys, Isabelle
Published in Current controlled trials in cardiovascular medicine

A new inhibitor of the β-arrestin/AP2 endocytic complex reveals interplay between GPCR internalization and signalling

by Beautrait, Alexandre, Paradis, Justine S, Zimmerman, Brandon, Giubilaro, Jenna, Nikolajev, Ljiljana, Armando, Sylvain, Kobayashi, Hiroyuki, Yamani, Lama, Namkung, Yoon, Heydenreich, Franziska M, Khoury, Etienne, Audet, Martin, Roux, Philippe P, Veprintsev, Dmitry B, Laporte, Stéphane A, Bouvier, Michel
Published in Nature communications

Machine learning–based integration of network features and chemical structure of compounds for SARS‐CoV‐2 drug effect analysis

by Späth, Julian, Wang, Rui‐Sheng, Humphrey, Maeve, Baumbach, Jan, Loscalzo, Joseph
Published in CPT: pharmacometrics and systems pharmacology

The Risks of miRNA Therapeutics: In a Drug Target Perspective

by Zhang, Song, Cheng, Zhujun, Wang, Yanan, Han, Tianyu
Published in Drug design, development and therapy

Clinical and translational pharmacology of the cathepsin K inhibitor odanacatib studied for osteoporosis

by Stone, Julie A., McCrea, Jacqueline B., Witter, Rose, Zajic, Stefan, Stoch, S. Aubrey
Published in British journal of clinical pharmacology

Clinical Research on Alzheimer’s Disease: Progress and Perspectives

by Sun, Bin-Lu, Li, Wei-Wei, Zhu, Chi, Jin, Wang-Sheng, Zeng, Fan, Liu, Yu-Hui, Bu, Xian-Le, Zhu, Jie, Yao, Xiu-Qing, Wang, Yan-Jiang
Published in Neuroscience bulletin

Current status and future outlook for patient‐derived cancer models from a rare cancer research perspective

by Kondo, Tadashi
Published in Cancer science

Small-molecule inhibitors, immune checkpoint inhibitors, and more: FDA-approved novel therapeutic drugs for solid tumors from 1991 to 2021

by Wu, Qing, Qian, Wei, Sun, Xiaoli, Jiang, Shaojie
Published in Journal of hematology and oncology

Engineering cytokines for cancer immunotherapy: a systematic review

by Fu, Yong, Tang, Renhong, Zhao, Xiaofeng
Published in Frontiers in immunology

Anti-TACI single and dual-targeting CAR T cells overcome BCMA antigen loss in multiple myeloma

by Larson, Rebecca C, Kann, Michael C, Graham, Charlotte, Mount, Christopher W, Castano, Ana P, Lee, Won-Ho, Bouffard, Amanda A, Takei, Hana N, Almazan, Antonio J, Scarfó, Irene, Berger, Trisha R, Schmidts, Andrea, Frigault, Matthew J, Gallagher, Kathleen M E, Maus, Marcela V
Published in Nature communications

Chronic bryostatin-1 rescues autistic and cognitive phenotypes in the fragile X mice

by Cogram, Patricia, Alkon, Daniel L, Crockford, David, Deacon, Robert M J, Hurley, Michael J, Altimiras, Francisco, Sun, Miao-Kun, Tranfaglia, Michael
Published in Scientific reports

Quinolinate promotes macrophage-induced immune tolerance in glioblastoma through the NMDAR/PPARγ signaling axis

by Kesarwani, Pravin, Kant, Shiva, Zhao, Yi, Prabhu, Antony, Buelow, Katie L, Miller, C Ryan, Chinnaiyan, Prakash
Published in Nature communications