RNA profiles reveal signatures of future health and disease in pregnancy

by Rasmussen, Morten, Reddy, Mitsu, Nolan, Rory, Camunas-Soler, Joan, Khodursky, Arkady, Scheller, Nikolai M, Cantonwine, David E, Engelbrechtsen, Line, Mi, Jia Dai, Dutta, Arup, Brundage, Tiffany, Siddiqui, Farooq, Thao, Mainou, Gee, Elaine P S, La, Johnny, Baruch-Gravett, Courtney, Santillan, Mark K, Deb, Saikat, Ame, Shaali M, Ali, Said M, Adkins, Melanie, DePristo, Mark A, Lee, Manfred, Namsaraev, Eugeni, Gybel-Brask, Dorte Jensen, Skibsted, Lillian, Litch, James A, Santillan, Donna A, Sazawal, Sunil, Tribe, Rachel M, Roberts, James M, Jain, Maneesh, Høgdall, Estrid, Holzman, Claudia, Quake, Stephen R, Elovitz, Michal A, McElrath, Thomas F
Published in Nature (London)

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

by Mills, Evanna L, Ryan, Dylan G, Prag, Hiran A, Dikovskaya, Dina, Menon, Deepthi, Zaslona, Zbigniew, Jedrychowski, Mark P, Costa, Ana S H, Higgins, Maureen, Hams, Emily, Szpyt, John, Runtsch, Marah C, King, Martin S, McGouran, Joanna F, Fischer, Roman, Kessler, Benedikt M, McGettrick, Anne F, Hughes, Mark M, Carroll, Richard G, Booty, Lee M, Knatko, Elena V, Meakin, Paul J, Ashford, Michael L J, Modis, Louise K, Brunori, Gino, Sévin, Daniel C, Fallon, Padraic G, Caldwell, Stuart T, Kunji, Edmund R S, Chouchani, Edward T, Frezza, Christian, Dinkova-Kostova, Albena T, Hartley, Richard C, Murphy, Michael P, O'Neill, Luke A
Published in Nature (London)

Increased subaerial volcanism and the rise of atmospheric oxygen 2.5 billion years ago

by Kump, Lee R, Barley, Mark E
Published in Nature (London)

Systems vaccinology of the BNT162b2 mRNA vaccine in humans

by Arunachalam, Prabhu S, Scott, Madeleine K D, Hagan, Thomas, Li, Chunfeng, Feng, Yupeng, Wimmers, Florian, Grigoryan, Lilit, Trisal, Meera, Edara, Venkata Viswanadh, Lai, Lilin, Chang, Sarah Esther, Feng, Allan, Dhingra, Shaurya, Shah, Mihir, Lee, Alexandra S, Chinthrajah, Sharon, Sindher, Sayantani B, Mallajosyula, Vamsee, Gao, Fei, Sigal, Natalia, Kowli, Sangeeta, Gupta, Sheena, Pellegrini, Kathryn, Tharp, Gregory, Maysel-Auslender, Sofia, Hamilton, Sydney, Aoued, Hadj, Hrusovsky, Kevin, Roskey, Mark, Bosinger, Steven E, Maecker, Holden T, Boyd, Scott D, Davis, Mark M, Utz, Paul J, Suthar, Mehul S, Khatri, Purvesh, Nadeau, Kari C, Pulendran, Bali
Published in Nature (London)

Phosphodiesterase 9A controls nitric-oxide-independent cGMP and hypertrophic heart disease

by Lee, Dong I, Zhu, Guangshuo, Sasaki, Takashi, Cho, Gun-Sik, Hamdani, Nazha, Holewinski, Ronald, Jo, Su-Hyun, Danner, Thomas, Zhang, Manling, Rainer, Peter P, Bedja, Djahida, Kirk, Jonathan A, Ranek, Mark J, Dostmann, Wolfgang R, Kwon, Chulan, Margulies, Kenneth B, Van Eyk, Jennifer E, Paulus, Walter J, Takimoto, Eiki, Kass, David A
Published in Nature (London)

Identification of type 2 diabetes loci in 433,540 East Asian individuals

by Spracklen, Cassandra N, Horikoshi, Momoko, Kim, Young Jin, Lin, Kuang, Bragg, Fiona, Moon, Sanghoon, Suzuki, Ken, Tam, Claudia H T, Takeuchi, Fumihiko, Long, Jirong, Lim, Victor J Y, Chai, Jin-Fang, Chen, Chien-Hsiun, Yao, Jie, Choi, Hyeok Sun, Iyengar, Apoorva K, Perrin, Hannah J, Brotman, Sarah M, van de Bunt, Martijn, Gloyn, Anna L, Below, Jennifer E, Boehnke, Michael, Bowden, Donald W, Chambers, John C, Mahajan, Anubha, Ng, Maggie C Y, Petty, Lauren E, Zhang, Weihua, Morris, Andrew P, Adair, Linda S, Akiyama, Masato, Bian, Zheng, Chan, Juliana C N, Chang, Li-Ching, Chee, Miao-Li, Chen, Yii-Der Ida, Chen, Yuan-Tsong, Chen, Zhengming, Chuang, Lee-Ming, Du, Shufa, Gordon-Larsen, Penny, Gross, Myron, Guo, Xiuqing, Guo, Yu, Han, Sohee, Howard, Annie-Green, Huang, Wei, Hung, Yi-Jen, Hwang, Mi Yeong, Hwu, Chii-Min, Ichihara, Sahoko, Isono, Masato, Jang, Hye-Mi, Jiang, Guozhi, Jonas, Jost B, Kamatani, Yoichiro, Katsuya, Tomohiro, Kawaguchi, Takahisa, Khor, Chiea-Chuen, Kohara, Katsuhiko, Lee, Myung-Shik, Lee, Nanette R, Liu, Jianjun, Luk, Andrea O, Lv, Jun, Okada, Yukinori, Pereira, Mark A, Sabanayagam, Charumathi, Shi, Jinxiu, So, Wing Yee, Takahashi, Atsushi, Tomlinson, Brian, Xiang, Yong-Bing, Yamamoto, Ken, Yamauchi, Toshimasa, Yoon, Kyungheon, Yu, Canqing, Yuan, Jian-Min, Zhang, Liang, Igase, Michiya, Cho, Yoon Shin, Rotter, Jerome I, Wang, Ya-Xing, Sheu, Wayne H H, Wu, Jer-Yuarn, Cheng, Ching-Yu, Wong, Tien-Yin, Shu, Xiao-Ou, Kato, Norihiro, Tai, E-Shyong, Koh, Woon-Puay, Ma, Ronald C W, Maeda, Shiro, Millwood, Iona Y, Lee, Juyoung, Kadowaki, Takashi, Walters, Robin G, Kim, Bong-Jo, Mohlke, Karen L, Sim, Xueling
Published in Nature (London)

Baf60c is essential for function of BAF chromatin remodelling complexes in heart development

by Rossant, Janet, Bruneau, Benoit G, Lickert, Heiko, Takeuchi, Jun K, von Both, Ingo, Walls, Johnathon R, McAuliffe, Fionnuala, Lee Adamson, S, Mark Henkelman, R, Wrana, Jeffrey L
Published in Nature

Discovery of stimulation-responsive immune enhancers with CRISPR activation

by Simeonov, Dimitre R, Gowen, Benjamin G, Boontanrart, Mandy, Roth, Theodore L, Gagnon, John D, Mumbach, Maxwell R, Satpathy, Ansuman T, Lee, Youjin, Bray, Nicolas L, Chan, Alice Y, Lituiev, Dmytro S, Nguyen, Michelle L, Gate, Rachel E, Subramaniam, Meena, Li, Zhongmei, Woo, Jonathan M, Mitros, Therese, Ray, Graham J, Curie, Gemma L, Naddaf, Nicki, Chu, Julia S, Ma, Hong, Boyer, Eric, Van Gool, Frederic, Huang, Hailiang, Liu, Ruize, Tobin, Victoria R, Schumann, Kathrin, Daly, Mark J, Farh, Kyle K, Ansel, K Mark, Ye, Chun J, Greenleaf, William J, Anderson, Mark S, Bluestone, Jeffrey A, Chang, Howard Y, Corn, Jacob E, Marson, Alexander
Published in Nature (London)

Global reference mapping of human transcription factor footprints

by Vierstra, Jeff, Lazar, John, Sandstrom, Richard, Halow, Jessica, Lee, Kristen, Bates, Daniel, Diegel, Morgan, Dunn, Douglas, Neri, Fidencio, Haugen, Eric, Rynes, Eric, Reynolds, Alex, Nelson, Jemma, Johnson, Audra, Frerker, Mark, Buckley, Michael, Kaul, Rajinder, Meuleman, Wouter, Stamatoyannopoulos, John A
Published in Nature (London)

Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations

by O' ROAK, Brian J, VIVES, Laura, TURNER, Emily H, STANAWAY, Ian B, VERNOT, Benjamin, MALIG, Maika, BAKER, Carl, REFFLY, Beau, AKEY, Joshua M, BORENSTEIN, Elhanan, RIEDER, Mark J, NICKERSON, Deborah A, GIRIRAJAN, Santhosh, BERNIER, Raphael, SHENDURE, Jay, EICHLER, Evan E, KARAKOC, Emre, KRUMM, Niklas, COE, Bradley P, LEVY, Roie, KO, Arthur, LEE, Choli, SMITHY, Joshua D
Published in Nature (London)

Index and biological spectrum of human DNase I hypersensitive sites

by Meuleman, Wouter, Muratov, Alexander, Rynes, Eric, Halow, Jessica, Lee, Kristen, Bates, Daniel, Diegel, Morgan, Dunn, Douglas, Neri, Fidencio, Teodosiadis, Athanasios, Reynolds, Alex, Haugen, Eric, Nelson, Jemma, Johnson, Audra, Frerker, Mark, Buckley, Michael, Sandstrom, Richard, Vierstra, Jeff, Kaul, Rajinder, Stamatoyannopoulos, John
Published in Nature (London)

Dysregulated naive B cells and de novo autoreactivity in severe COVID-19

by Woodruff, Matthew C., Ramonell, Richard P., Haddad, Natalie S., Anam, Fabliha A., Rudolph, Mark E., Walker, Tiffany A., Truong, Alexander D., Dixit, Adviteeya N., Han, Jenny E., Cabrera-Mora, Monica, Runnstrom, Martin C., Bugrovsky, Regina, Hom, Jennifer, Connolly, Erin C., Albizua, Igor, Javia, Vidhi, Cashman, Kevin S., Nguyen, Doan C., Kyu, Shuya, Singh Saini, Ankur, Piazza, Michael, Tipton, Christopher M., Khosroshahi, Arezou, Gibson, Greg, Martin, Greg S., Maier, Cheryl L., Esper, Annette, Jenks, Scott A., Lee, F. Eun-Hyung, Sanz, Ignacio
Published in Nature (London)

Regulation of distinct AMPA receptor phosphorylation sites during bidirectional synaptic plasticity

by Huganir, Richard L, Lee, Hey-Kyoung, Barbarosie, Michaela, Kameyama, Kimihiko, Bear, Mark F
Published in Nature (London)

Structures of β-klotho reveal a 'zip code'-like mechanism for endocrine FGF signalling

by Lee, Sangwon, Choi, Jungyuen, Mohanty, Jyotidarsini, Sousa, Leiliane P, Tome, Francisco, Pardon, Els, Steyaert, Jan, Lemmon, Mark A, Lax, Irit, Schlessinger, Joseph
Published in Nature (London)

BET inhibitor resistance emerges from leukaemia stem cells

by Fong, Chun Yew, Gilan, Omer, Lam, Enid Y N, Rubin, Alan F, Ftouni, Sarah, Tyler, Dean, Stanley, Kym, Sinha, Devbarna, Yeh, Paul, Morison, Jessica, Giotopoulos, George, Lugo, Dave, Jeffrey, Philip, Lee, Stanley Chun-Wei, Carpenter, Christopher, Gregory, Richard, Ramsay, Robert G, Lane, Steven W, Abdel-Wahab, Omar, Kouzarides, Tony, Johnstone, Ricky W, Dawson, Sarah-Jane, Huntly, Brian J P, Prinjha, Rab K, Papenfuss, Anthony T, Dawson, Mark A
Published in Nature (London)

Observation of molecular orbital gating

by Kim, Youngsang, Jeong, Heejun, Song, Hyunwook, Lee, Takhee, Jang, Yun Hee, Reed, Mark A
Published in Nature (London)

Necroptosis blockade prevents lung injury in severe influenza

by Gautam, Avishekh, Boyd, David F, Nikhar, Sameer, Zhang, Ting, Siokas, Ioannis, Van de Velde, Lee-Ann, Gaevert, Jessica, Meliopoulos, Victoria, Thapa, Bikash, Rodriguez, Diego A, Cai, Kathy Q, Yin, Chaoran, Schnepf, Daniel, Beer, Julius, DeAntoneo, Carly, Williams, Riley M, Shubina, Maria, Livingston, Brandi, Zhang, Dingqiang, Andrake, Mark D, Lee, Seungheon, Boda, Raghavender, Duddupudi, Anantha L, Crawford, Jeremy Chase, Vogel, Peter, Loch, Christian, Schwemmle, Martin, Fritz, Lawrence C, Schultz-Cherry, Stacey, Green, Douglas R, Cuny, Gregory D, Thomas, Paul G, Degterev, Alexei, Balachandran, Siddharth
Published in Nature (London)

Schizophrenia risk from complex variation of complement component 4

by Sekar, Aswin, Bialas, Allison R, de Rivera, Heather, Davis, Avery, Hammond, Timothy R, Kamitaki, Nolan, Tooley, Katherine, Presumey, Jessy, Baum, Matthew, Van Doren, Vanessa, Genovese, Giulio, Rose, Samuel A, Handsaker, Robert E, Daly, Mark J, Carroll, Michael C, Stevens, Beth, McCarroll, Steven A
Published in Nature (London)

Precise interpolar phasing of abrupt climate change during the last ice age

by Buizert, Christo, Adrian, Betty, Ahn, Jinho, Albert, Mary, Alley, Richard B, Baggenstos, Daniel, Bauska, Thomas K, Bay, Ryan C, Bencivengo, Brian B, Bentley, Charles R, Brook, Edward J, Chellman, Nathan J, Clow, Gary D, Cole-Dai, Jihong, Conway, Howard, Cravens, Eric, Cuffey, Kurt M, Dunbar, Nelia W, Edwards, Jon S, Fegyveresi, John M, Ferris, Dave G, Fitzpatrick, Joan J, Fudge, T J, Gibson, Chris J, Gkinis, Vasileios, Goetz, Joshua J, Gregory, Stephanie, Hargreaves, Geoffrey M, Iverson, Nels, Johnson, Jay A, Jones, Tyler R, Kalk, Michael L, Kippenhan, Matthew J, Koffman, Bess G, Kreutz, Karl, Kuhl, Tanner W, Lebar, Donald A, Lee, James E, Marcott, Shaun A, Markle, Bradley R, Maselli, Olivia J, McConnell, Joseph R, McGwire, Kenneth C, Mitchell, Logan E, Mortensen, Nicolai B, Neff, Peter D, Nishiizumi, Kunihiko, Nunn, Richard M, Orsi, Anais J, Pasteris, Daniel R, Pedro, Joel B, Pettit, Erin C, Price, P Buford, Priscu, John C, Rhodes, Rachael H, Rosen, Julia L, Schauer, Andrew J, Schoenemann, Spruce W, Sendelbach, Paul J, Severinghaus, Jeffrey P, Shturmakov, Alexander J, Sigl, Michael, Slawny, Kristina R, Souney, Joseph M, Sowers, Todd A, Spencer, Matthew K, Steig, Eric J, Taylor, Kendrick C, Twickler, Mark S, Vaughn, Bruce H, Voigt, Donald E, Waddington, Edwin D, Welten, Kees C, Wendricks, Anthony W, White, James W C, Winstrup, Mai, Wong, Gifford J, Woodruff, Thomas E
Published in Nature (London)

A map of human genome variation from population-scale sequencing

by Abecasis, Gonçalo R, Altshuler, David, Auton, Adam, Brooks, Lisa D, Durbin, Richard M, Gibbs, Richard A, Hurles, Matt E, McVean, Gil A
Published in Nature (London)