C/EBPB-dependent adaptation to palmitic acid promotes tumor formation in hormone receptor negative breast cancer

by Liu, Xiao-Zheng, Rulina, Anastasiia, Choi, Man Hung, Pedersen, Line, Lepland, Johanna, Takle, Sina T, Madeleine, Noelly, Peters, Stacey D'mello, Wogsland, Cara Ellen, Grøndal, Sturla Magnus, Lorens, James B, Goodarzi, Hani, Lønning, Per E, Knappskog, Stian, Molven, Anders, Halberg, Nils
Published in Nature communications

Ecosystem resilience despite large-scale altered hydroclimatic conditions

by PONCE CAMPOS, Guillermo E, SUSAN MORAN, M, HEARTSILL SCALLEY, Tamara, KITCHEN, Stanley G, MCCLARAN, Mitchel P, HENRY MCNABLL, W, MONTOYA, Diane S, MORGAN, Jack A, PETERS, Debra P. C, SADLER, E. John, SEYFRIED, Mark S, STARKS, Patrick J, HUETE, Alfredo, YONGGUANG ZHANG, BRESLOFF, Cynthia, HUXMAN, Travis E, EAMUS, Derek, BOSCH, David D, BUDA, Anthony R, GUNTER, Stacey A
Published in Nature (London)

Genomic atlas of the human plasma proteome

by Sun, Benjamin B, Maranville, Joseph C, Peters, James E, Stacey, David, Staley, James R, Blackshaw, James, Burgess, Stephen, Jiang, Tao, Paige, Ellie, Surendran, Praveen, Oliver-Williams, Clare, Kamat, Mihir A, Prins, Bram P, Wilcox, Sheri K, Zimmerman, Erik S, Chi, An, Bansal, Narinder, Spain, Sarah L, Wood, Angela M, Morrell, Nicholas W, Bradley, John R, Janjic, Nebojsa, Roberts, David J, Ouwehand, Willem H, Todd, John A, Soranzo, Nicole, Suhre, Karsten, Paul, Dirk S, Fox, Caroline S, Plenge, Robert M, Danesh, John, Runz, Heiko, Butterworth, Adam S
Published in Nature (London)

A global reference for human genetic variation

by Auton, Adam, Brooks, Lisa D, Durbin, Richard M, Garrison, Erik P, Kang, Hyun Min, Korbel, Jan O, Marchini, Jonathan L, McCarthy, Shane, McVean, Gil A, Abecasis, Gonçalo R
Published in Nature (London)

Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants

by Fu, Wenqing, O'Connor, Timothy D, Jun, Goo, Kang, Hyun Min, Abecasis, Goncalo, Leal, Suzanne M, Gabriel, Stacey, Rieder, Mark J, Altshuler, David, Shendure, Jay, Nickerson, Deborah A, Bamshad, Michael J, Akey, Joshua M
Published in Nature (London)

Parental origin of sequence variants associated with complex diseases

by Gudjonsson, Sigurjon A, Sigurdsson, Helgi, Kristinsson, Kari Th, Sigurdsson, Asgeir, Hreidarsson, Astradur B, Masson, Gisli, Ferguson-Smith, Anne C, Frigge, Michael L, Jonsson, Thorvaldur, Stacey, Simon N, Olafsson, Jon H, Benediktsdottir, Kristrun R, Gudbjartsson, Daniel F, Besenbacher, Soren, Gylfason, Arnaldur, Sigurgeirsson, Bardur, Olason, Pall I, Sverrisson, Sverrir, Stefansson, Kari, Johannsson, Oskar Th, Thorsteinsdottir, Unnur, Benediktsson, Rafn, Thorleifsson, Gudmar, Kong, Augustine, Steinthorsdottir, Valgerdur, Sulem, Patrick, Jonasdottir, Aslaug, Jonasdottir, Adalbjorg, Sigurdsson, Gunnar
Published in Nature (London)

Exuberant fibroblast activity compromises lung function via ADAMTS4

by Boyd, David F, Allen, E Kaitlynn, Randolph, Adrienne G, Guo, Xi-Zhi J, Weng, Yunceng, Sanders, Catherine J, Bajracharya, Resha, Lee, Natalie K, Guy, Clifford S, Vogel, Peter, Guan, Wenda, Li, Yimin, Liu, Xiaoqing, Novak, Tanya, Newhams, Margaret M, Fabrizio, Thomas P, Wohlgemuth, Nicholas, Mourani, Peter M, Wight, Thomas N, Schultz-Cherry, Stacey, Cormier, Stephania A, Shaw-Saliba, Kathryn, Pekosz, Andrew, Rothman, Richard E, Chen, Kuan-Fu, Yang, Zifeng, Webby, Richard J, Zhong, Nanshan, Crawford, Jeremy Chase, Thomas, Paul G
Published in Nature (London)

Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction

by Do, Ron, Stitziel, Nathan O, Won, Hong-Hee, Jørgensen, Anders Berg, Duga, Stefano, Angelica Merlini, Pier, Kiezun, Adam, Farrall, Martin, Goel, Anuj, Zuk, Or, Guella, Illaria, Asselta, Rosanna, Lange, Leslie A, Peloso, Gina M, Auer, Paul L, Girelli, Domenico, Martinelli, Nicola, Farlow, Deborah N, DePristo, Mark A, Roberts, Robert, Stewart, Alexander F R, Saleheen, Danish, Danesh, John, Epstein, Stephen E, Sivapalaratnam, Suthesh, Hovingh, G Kees, Kastelein, John J, Samani, Nilesh J, Schunkert, Heribert, Erdmann, Jeanette, Shah, Svati H, Kraus, William E, Davies, Robert, Nikpay, Majid, Johansen, Christopher T, Wang, Jian, Hegele, Robert A, Hechter, Eliana, Marz, Winfried, Kleber, Marcus E, Huang, Jie, Johnson, Andrew D, Li, Mingyao, Burke, Greg L, Gross, Myron, Liu, Yongmei, Assimes, Themistocles L, Heiss, Gerardo, Lange, Ethan M, Folsom, Aaron R, Taylor, Herman A, Olivieri, Oliviero, Hamsten, Anders, Clarke, Robert, Reilly, Dermot F, Yin, Wu, Rivas, Manuel A, Donnelly, Peter, Rossouw, Jacques E, Psaty, Bruce M, Herrington, David M, Wilson, James G, Rich, Stephen S, Bamshad, Michael J, Tracy, Russell P, Cupples, L Adrienne, Rader, Daniel J, Reilly, Muredach P, Spertus, John A, Cresci, Sharon, Hartiala, Jaana, Tang, W H Wilson, Hazen, Stanley L, Allayee, Hooman, Reiner, Alex P, Carlson, Christopher S, Kooperberg, Charles, Jackson, Rebecca D, Boerwinkle, Eric, Lander, Eric S, Schwartz, Stephen M, Siscovick, David S, McPherson, Ruth, Tybjaerg-Hansen, Anne, Abecasis, Goncalo R, Watkins, Hugh, Nickerson, Deborah A, Ardissino, Diego, Sunyaev, Shamil R, O'Donnell, Christopher J, Altshuler, David, Gabriel, Stacey, Kathiresan, Sekar
Published in Nature (London)

A versatile reverse genetics platform for SARS-CoV-2 and other positive-strand RNA viruses

by Amarilla, Alberto A., Sng, Julian D. J., Parry, Rhys, Deerain, Joshua M., Potter, James R., Setoh, Yin Xiang, Rawle, Daniel J., Le, Thuy T., Modhiran, Naphak, Wang, Xiaohui, Peng, Nias Y. G., Torres, Francisco J., Pyke, Alyssa, Harrison, Jessica J., Freney, Morgan E., Liang, Benjamin, McMillan, Christopher L. D., Cheung, Stacey T. M., Guevara, Darwin J. Da Costa, Hardy, Joshua M., Bettington, Mark, Muller, David A., Coulibaly, Fasséli, Moore, Frederick, Hall, Roy A., Young, Paul R., Mackenzie, Jason M., Hobson-Peters, Jody, Suhrbier, Andreas, Watterson, Daniel, Khromykh, Alexander A.
Published in Nature communications

Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche

by Ferreira, Teresa, He, Chunyan, Esko, Tõnu, Thorleifsson, Gudmar, Albrecht, Eva, Corre, Tanguy, Franceschini, Nora, Ganna, Andrea, Porcu, Eleonora, Stolk, Lisette, Tšernikova, Natalia, Tikkanen, Emmi, Wagner, Erin K, Hottenga, Jouke-Jan, Mangino, Massimo, Pers, Tune H, Atsma, Femke, Beckmann, Matthias W, Benitez, Javier, Blomqvist, Carl, Bojesen, Stig E, Bolla, Manjeet K, Brauch, Hiltrud, Brenner, Hermann, Buring, Julie E, Chanock, Stephen, Chen, Jinhui, Chenevix-Trench, Georgia, Couch, Fergus J, Czene, Kamila, D'adamo, Adamo Pio, Smith, George Davey, De Vivo, Immaculata, Demerath, Ellen W, Dennis, Joe, Dunning, Alison M, Eriksson, Johan G, Ferrucci, Luigi, Flesch-Janys, Dieter, Flyger, Henrik, Garcia, Melissa E, García-Closas, Montserrat, Gudnason, Vilmundur, Guénel, Pascal, Hall, Per, Hamann, Ute, Haring, Robin, Hartman, Catharina A, Heath, Andrew C, Hofman, Albert, Hu, Frank B, Karasik, David, Kosma, Veli-Matti, Kutalik, Zoltan, Lai, Sandra, Lindblom, Annika, Mägi, Reedik, Melbye, Mads, Michailidou, Kyriaki, Nevanlinna, Heli, Neven, Patrick, Nohr, Ellen A, Oostra, Ben A, Palotie, Aarno, Peterlongo, Paolo, Peto, Julian, Postma, Dirkje S, Pylkäs, Katri, Radice, Paolo, Ring, Susan, Rivadeneira, Fernando, Rose, Lynda M, Rudolph, Anja, Sanna, Serena, Southey, Mellissa C, Visser, Jenny A, Waldenberger, Melanie, Wallaschofski, Henri, Wolffenbuttel, Bruce Hr, Wright, Margaret J, Econs, Michael J, Khaw, Kay-Tee, Montgomery, Grant W, Streeten, Elizabeth A, Thorsteinsdottir, Unnur, Bergmann, Sven, Crisponi, Laura, Gasparini, Paolo, Gieger, Christian, Harris, Tamara B, Ingelsson, Erik, Järvelin, Marjo-Riitta, Kraft, Peter, Lawlor, Debbie, Metspalu, Andres, Pennell, Craig E, Zygmunt, Marek, Murray, Anna, Stefansson, Kari, Ong, Ken K
Published in Nature (London)

A structural variation reference for medical and population genetics

by Collins, Ryan L, Brand, Harrison, Karczewski, Konrad J, Zhao, Xuefang, Alföldi, Jessica, Francioli, Laurent C, Khera, Amit V, Lowther, Chelsea, Gauthier, Laura D, Wang, Harold, Watts, Nicholas A, Solomonson, Matthew, O'Donnell-Luria, Anne, Baumann, Alexander, Munshi, Ruchi, Walker, Mark, Whelan, Christopher W, Huang, Yongqing, Brookings, Ted, Sharpe, Ted, Stone, Matthew R, Valkanas, Elise, Fu, Jack, Tiao, Grace, Laricchia, Kristen M, Ruano-Rubio, Valentin, Stevens, Christine, Gupta, Namrata, Cusick, Caroline, Margolin, Lauren, Taylor, Kent D, Lin, Henry J, Rich, Stephen S, Post, Wendy S, Chen, Yii-Der Ida, Rotter, Jerome I, Nusbaum, Chad, Philippakis, Anthony, Lander, Eric, Gabriel, Stacey, Neale, Benjamin M, Kathiresan, Sekar, Daly, Mark J, Banks, Eric, MacArthur, Daniel G, Talkowski, Michael E
Published in Nature (London)

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

by Teumer, Alexander, Li, Man, Garnaas, Maija, Taliun, Daniel, Yang, Qiong, Ko, Yi-An, Isaacs, Aaron, d'Adamo, Pio, Dieffenbach, Aida Karina, Zonderman, Alan B, Nolte, Ilja M, Smith, Albert V, Uitterlinden, Andre G, Johansson, Åsa, Kollerits, Barbara, Freedman, Barry I, Ponte, Belen, Hayward, Caroline, Helmer, Catherine, van Duijn, Cornelia M, Ruggiero, Daniela, Toniolo, Daniela, Czamara, Darina, Siscovick, David S, Gieger, Christian, Rochtchina, Elena, Holliday, Elizabeth G, Salvi, Erika, Bottinger, Erwin P, Murgia, Federico, Rivadeneira, Fernando, Ernst, Florian, Kronenberg, Florian, Homuth, Georg, Coassin, Stefan, Thun, Gian-Andri, Malerba, Giovanni, Montgomery, Grant W, Eiriksdottir, Gudny, Jacobs, Gunnar, Li, Guo, Schmidt, Helena, Lin, Honghuang, Ford, Ian, Prokopenko, Inga, Kolcic, Ivana, Stafford, Jeanette M, Gaspoz, Jean-Michel, Smith, Jennifer A, Hirschhorn, Joel N, Whitfield, John B, Coresh, Josef, Keene, Keith L, Yengo, Loic, Ferrucci, Luigi, Rose, Lynda M, Struchalin, Maksim, Kleber, Marcus E, Cavalieri, Margherita, Haun, Margot, Ciullo, Marina, Woodward, Mark, Cocca, Massimiliano, Nauck, Matthias, Waldenberger, Melanie, Pruijm, Menno, Stumvoll, Michael, Kähönen, Mika, Bouatia-Naji, Nabila, Martin, Nicholas G, Hastie, Nick, Probst-Hensch, Nicole, Devuyst, Olivier, Raitakari, Olli, Gasparini, Paolo, Kovacs, Peter, Wild, Philipp S, Froguel, Philippe, Biffar, Reiner, Schmidt, Reinhold, Scott, Rodney J, Katz, Ronit, Hwang, Shih-Jen, Enroth, Stefan, Turner, Stephen T, Zeller, Tanja, Nikopensius, Tiit, Esko, Tonu, Aalto, Ville, Igl, Wilmar, Lieb, Wolfgang, Liu, Yongmei, Snieder, Harold, Susztak, Katalin, Hamet, Pavel, Goessling, Wolfram, Chasman, Daniel I, Köttgen, Anna, Kao, W H Linda, Fox, Caroline S
Published in Nature communications

Strain- and host species-specific inflammasome activation, IL-1β release, and cell death in macrophages infected with uropathogenic Escherichia coli

by Schaale, K, Peters, K M, Murthy, A M, Fritzsche, A K, Phan, M-D, Totsika, M, Robertson, A A B, Nichols, K B, Cooper, M A, Stacey, K J, Ulett, G C, Schroder, K, Schembri, M A, Sweet, M J
Published in Mucosal immunology

Common polygenic variation contributes to risk of schizophrenia and bipolar disorder

by Purcell, Shaun M, Wray, Naomi R, Stone, Jennifer L, Visscher, Peter M, O'Donovan, Michael C, Sullivan, Patrick F, Sklar, Pamela
Published in Nature (London)

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

by Munroe, Patricia B, Smith, Albert V, Verwoert, Germaine C, Amin, Najaf, Teumer, Alexander, Zhao, Jing Hua, Parsa, Afshin, Dehghan, Abbas, Peden, John F, Rudan, Igor, Chambers, John C, Fox, Ervin R, Alexander, Myriam, Tabara, Yasuharu, Seielstad, Mark, Kuznetsova, Tatiana, Ludwig, Barbara, Tomaszewski, Maciej, O'Connell, Jeffrey R, Kardia, Sharon L, Hingorani, Aroon D, Lawlor, Debbie A, Lawrence, Robert W, Clarke, Robert, Ongen, Halit, Li, Yali, Adair, Linda S, Lee, Nanette R, Bolton, Judith A Hoffman, Chaturvedi, Nish, Islam, Muhammad, Kulkarni, Smita R, Groop, Leif, Voight, Benjamin F, Guarrera, Simonetta, Plump, Andrew, Barroso, Inês, Vartiainen, Erkki, Burton, Paul R, Dong, Yanbin, Wang, Xiaoling, Lohman, Kurt K, Smith, Nicholas L, Kinra, Sanjay, Prabhakaran, Dorairaj, Forrester, Terrence, Hilton, Gina, McKenzie, Colin A, Kita, Yoshikuni, Wichmann, H-Erich, Zhang, Weihua, Hedblad, Bo, Nilsson, Peter, Wong, Andrew, Raffel, Leslie J, Yao, Jie, Schwartz, Stephen M, Ikram, M Arfan, Rasheed, Asif, Watkins, Hugh, Bakker, Stephan J L, van Gilst, Wiek H, Janipalli, Charles S, Rivadeneira, Fernando, Ala-Korpela, Mika, Soininen, Pasi, Völzke, Henry, Lathrop, Mark, Zelenika, Diana, Deloukas, Panos, Mangino, Massimo, Zhai, Guangju, Nalls, Michael A, Terzic, Janos, Kumar, M V Kranthi, Charchar, Fadi J, Schwarz, Peter E H, Guo, Xiuqing, Bots, Michiel L, Samani, Nilesh J, Palmer, Lyle J, Casas, Juan P, Vineis, Paolo, Raitakari, Olli, Wong, Tien Y, Tai, E Shyong, Cooper, Richard S, Rao, Dabeeru C, Harris, Tamara B, Morris, Richard W, Kivimaki, Mika, Coresh, Josef, Navis, Gerjan, Han, Bok-Ghee, Melander, Olle, Gyllensten, Ulf B, Rettig, Rainer, Uda, Manuela, Psaty, Bruce M, Abecasis, Gonçalo R
Published in Nature (London)

Integrated genomic characterization of oesophageal carcinoma

by Odze, Robert D, Meier, Samuel R, Wu, Hsin-Ta, Wong, Alexandra M, McCall, Shannon J, Wiznerowicz, Maciej, Parfenov, Michael, Arora, Arshi, Weinhold, Nils, Demchok, John, Zenklusen, Jean Claude, Lichtenberg, Tara M, Curtis, Christina, Luketich, James D, Zhou, Zhongren, Akbani, Rehan, Liu, Wenbin, Piazuelo, M. Blanca, McLellan, Michael, Stewart, Chip, Gabriel, Stacey B, McLellan, Michael D, Appelbaum, Elizabeth L, Cordes, Matthew G, Fronick, Catrina C, Fulton, Lucinda A, Wilson, Richard K, Balasundaram, Miruna, Carlsen, Rebecca, Dhalla, Noreen, Brooks, Denise, Mungall, Karen L, Schein, Jacqueline E, Sipahimalani, Payal, Park, Peter J, Yang, Lixing, Baylin, Stephen B, Bootwalla, Moiz S, Berrios, Mario, Holbrook, Andrea, Hwang, Jun-Eul, Weinstein, John N, Seth, Sahil, Protopopov, Alexei, Bristow, Christopher A, Mahadeshwar, Harshad S, Zhang, Jianhua, Defrietas, Timothy, Heiman, David I, Lawrence, Michael S, Lin, Pei, Zhang, Hailei, Bernard, Brady, Reynolds, Sheila M, Kundra, Ritika, Ladanyi, Marc, Sander, Chris, Crain, Daniel, Shelton, Troy, Frick, Jessica, Leraas, Kristen M, Tarvin, Katherine, Saller, Charles, Park, Young Soo, de Oliveira, Antonio Talvane, Paklina, Oxana, Lee, Jae-Hyuck, Bennett, Joseph, Iacocca, Mary, Voronina, Olga, Liu, Ouida, Cates, Crystal, Sharp, Alexis, Behera, Madhusmitara, Pickens, Allan, Ramalingam, Suresh, Sica, Gabriel, Dinjens, Winand, Juhl, Hartmut, Bartlett, John, Parfitt, Jeremy, Darling, Gail, El-Zimaity, Haila, Kemp, Rafael, Sankarankutty, Ajith Kumar, Trevisan, Felipe Amstalden, Godwin, Andrew, Ferrer-Torres, Daysha, Vinco, Michele, Ajani, Jaffer A, Tang, Laura, Cheong, Jae-Ho, Naresh, Rashi, Sun, Qiang, Demchok, John A, Shaw, Kenna R. Mills, Wang, Zhining, Yang, Liming, Sofia, Heidi J, Zhang, Jiashan
Published in Nature (London)

Comprehensive molecular characterization of urothelial bladder carcinoma

by Weinstein, John N, Akbani, Rehan, Broom, Bradley M, Wang, Wenyi, Verhaak, Roeland G. W, McConkey, David
Published in Nature (London)

Assessment of established techniques to determine developmental and malignant potential of human pluripotent stem cells

by Allison, Thomas F., Andrews, Peter W., Avior, Yishai, Barbaric, Ivana, Benvenisty, Nissim, Bock, Christoph, Brehm, Jennifer, Brüstle, Oliver, Damjanov, Ivan, Elefanty, Andrew, Felkner, Daniel, Gokhale, Paul J., Halbritter, Florian, Healy, Lyn E., Hu, Tim X., Knowles, Barbara B., Loring, Jeanne F., Ludwig, Tenneille E., Mayberry, Robyn, Micallef, Suzanne, Mohamed, Jameelah S., Müller, Franz-Josef, Mummery, Christine L., Nakatsuji, Norio, Ng, Elizabeth S., Oh, Steve K. W., O’Shea, Orla, Pera, Martin F., Reubinoff, Benjamin, Robson, Paul, Rossant, Janet, Schuldt, Bernhard M., Solter, Davor, Sourris, Koula, Stacey, Glyn, Stanley, Edouard G., Suemori, Hirofumi, Takahashi, Kazutoshi, Yamanaka, Shinya
Published in Nature communications

An integrated map of genetic variation from 1,092 human genomes

by Abecasis, Goncalo R, Auton, Adam, Brooks, Lisa D, DePristo, Mark A, Durbin, Richard M, Handsaker, Robert E, Kang, Hyun Min, Marth, Gabor T, McVean, Gil A
Published in Nature (London)

Transcript expression-aware annotation improves rare variant interpretation

by Cummings, Beryl B, Karczewski, Konrad J, Kosmicki, Jack A, Seaby, Eleanor G, Watts, Nicholas A, Singer-Berk, Moriel, Mudge, Jonathan M, Karjalainen, Juha, Satterstrom, F Kyle, O'Donnell-Luria, Anne H, Poterba, Timothy, Seed, Cotton, Solomonson, Matthew, Alföldi, Jessica, Daly, Mark J, MacArthur, Daniel G
Published in Nature (London)