Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts

by Vimaleswaran, Karani S, Berry, Diane J, Lu, Chen, Tikkanen, Emmi, Pilz, Stefan, Hiraki, Linda T, Cooper, Jason D, Dastani, Zari, Li, Rui, Houston, Denise K, Wood, Andrew R, Michaëlsson, Karl, Vandenput, Liesbeth, Zgaga, Lina, Yerges-Armstrong, Laura M, McCarthy, Mark I, Dupuis, Josée, Kaakinen, Marika, Kleber, Marcus E, Jameson, Karen, Arden, Nigel, Raitakari, Olli, Viikari, Jorma, Lohman, Kurt K, Ferrucci, Luigi, Melhus, Håkan, Ingelsson, Erik, Byberg, Liisa, Lind, Lars, Lorentzon, Mattias, Salomaa, Veikko, Campbell, Harry, Dunlop, Malcolm, Mitchell, Braxton D, Herzig, Karl-Heinz, Pouta, Anneli, Hartikainen, Anna-Liisa, Streeten, Elizabeth A, Theodoratou, Evropi, Jula, Antti, Wareham, Nicholas J, Ohlsson, Claes, Frayling, Timothy M, Kritchevsky, Stephen B, Spector, Timothy D, Richards, J Brent, Lehtimäki, Terho, Ouwehand, Willem H, Kraft, Peter, Cooper, Cyrus, März, Winfried, Power, Chris, Loos, Ruth J F, Wang, Thomas J, Järvelin, Marjo-Riitta, Whittaker, John C, Hingorani, Aroon D, Hyppönen, Elina
Published in PLoS medicine

Serum iron levels and the risk of Parkinson disease: a Mendelian randomization study

by Pichler, Irene, Del Greco M, Fabiola, Gögele, Martin, Lill, Christina M, Bertram, Lars, Do, Chuong B, Eriksson, Nicholas, Foroud, Tatiana, Myers, Richard H, Nalls, Michael, Keller, Margaux F, Benyamin, Beben, Whitfield, John B, Pramstaller, Peter P, Hicks, Andrew A, Thompson, John R, Minelli, Cosetta
Published in PLoS medicine

Admixture mapping of 15,280 African Americans identifies obesity susceptibility loci on chromosomes 5 and X

by Cheng, Ching-Yu, Kao, W H Linda, Patterson, Nick, Tandon, Arti, Haiman, Christopher A, Harris, Tamara B, Xing, Chao, John, Esther M, Ambrosone, Christine B, Brancati, Frederick L, Coresh, Josef, Press, Michael F, Parekh, Rulan S, Klag, Michael J, Meoni, Lucy A, Hsueh, Wen-Chi, Fejerman, Laura, Pawlikowska, Ludmila, Freedman, Matthew L, Jandorf, Lina H, Bandera, Elisa V, Ciupak, Gregory L, Nalls, Michael A, Akylbekova, Ermeg L, Orwoll, Eric S, Leak, Tennille S, Miljkovic, Iva, Li, Rongling, Ursin, Giske, Bernstein, Leslie, Ardlie, Kristin, Taylor, Herman A, Boerwinckle, Eric, Zmuda, Joseph M, Henderson, Brian E, Wilson, James G, Reich, David
Published in PLoS genetics

Biological interpretation of genome-wide association studies using predicted gene functions

by Pers, Tune H, Karjalainen, Juha M, Chan, Yingleong, Westra, Harm-Jan, Wood, Andrew R, Yang, Jian, Lui, Julian C, Vedantam, Sailaja, Gustafsson, Stefan, Esko, Tonu, Frayling, Tim, Speliotes, Elizabeth K, Boehnke, Michael, Raychaudhuri, Soumya, Fehrmann, Rudolf S N, Hirschhorn, Joel N, Franke, Lude
Published in Nature communications

Characterising the loss-of-function impact of 5' untranslated region variants in 15,708 individuals

by Whiffin, Nicola, Karczewski, Konrad J, Zhang, Xiaolei, Chothani, Sonia, Smith, Miriam J, Evans, D Gareth, Roberts, Angharad M, Quaife, Nicholas M, Schafer, Sebastian, Rackham, Owen, Alföldi, Jessica, O'Donnell-Luria, Anne H, Francioli, Laurent C, Cook, Stuart A, Barton, Paul J R, MacArthur, Daniel G, Ware, James S
Published in Nature communications

Associations between Potentially Modifiable Risk Factors and Alzheimer Disease: A Mendelian Randomization Study

by Østergaard, Søren D, Mukherjee, Shubhabrata, Sharp, Stephen J, Proitsi, Petroula, Lotta, Luca A, Day, Felix, Perry, John R B, Boehme, Kevin L, Walter, Stefan, Kauwe, John S, Gibbons, Laura E, Larson, Eric B, Powell, John F, Langenberg, Claudia, Crane, Paul K, Wareham, Nicholas J, Scott, Robert A
Published in PLoS medicine

Interethnic analyses of blood pressure loci in populations of East Asian and European descent

by Takeuchi, Fumihiko, Akiyama, Masato, Matoba, Nana, Katsuya, Tomohiro, Nakatochi, Masahiro, Tabara, Yasuharu, Narita, Akira, Saw, Woei-Yuh, Moon, Sanghoon, Spracklen, Cassandra N, Chai, Jin-Fang, Kim, Young-Jin, Zhang, Liang, Wang, Chaolong, Li, Huaixing, Li, Honglan, Wu, Jer-Yuarn, Dorajoo, Rajkumar, Nierenberg, Jovia L, Wang, Ya Xing, He, Jing, Bennett, Derrick A, Takahashi, Atsushi, Momozawa, Yukihide, Hirata, Makoto, Matsuda, Koichi, Rakugi, Hiromi, Nakashima, Eitaro, Isono, Masato, Shirota, Matsuyuki, Hozawa, Atsushi, Ichihara, Sahoko, Matsubara, Tatsuaki, Yamamoto, Ken, Kohara, Katsuhiko, Igase, Michiya, Han, Sohee, Gordon-Larsen, Penny, Huang, Wei, Lee, Nanette R, Adair, Linda S, Hwang, Mi Yeong, Lee, Juyoung, Chee, Miao Li, Sabanayagam, Charumathi, Zhao, Wanting, Liu, Jianjun, Reilly, Dermot F, Sun, Liang, Huo, Shaofeng, Edwards, Todd L, Long, Jirong, Chang, Li-Ching, Chen, Chien-Hsiun, Yuan, Jian-Min, Koh, Woon-Puay, Friedlander, Yechiel, Kelly, Tanika N, Bin Wei, Wen, Xu, Liang, Cai, Hui, Xiang, Yong-Bing, Lin, Kuang, Clarke, Robert, Walters, Robin G, Millwood, Iona Y, Li, Liming, Chambers, John C, Kooner, Jaspal S, Elliott, Paul, van der Harst, Pim, Chen, Zhengming, Sasaki, Makoto, Shu, Xiao-Ou, Jonas, Jost B, He, Jiang, Heng, Chew-Kiat, Chen, Yuan-Tsong, Zheng, Wei, Lin, Xu, Teo, Yik-Ying, Tai, E-Shyong, Cheng, Ching-Yu, Wong, Tien Yin, Sim, Xueling, Mohlke, Karen L, Yamamoto, Masayuki, Kim, Bong-Jo, Miki, Tetsuro, Nabika, Toru, Yokota, Mitsuhiro, Kamatani, Yoichiro, Kubo, Michiaki, Kato, Norihiro
Published in Nature communications

Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women

by Fox, Caroline S, Liu, Yongmei, White, Charles C, Feitosa, Mary, Smith, Albert V, Heard-Costa, Nancy, Lohman, Kurt, Johnson, Andrew D, Foster, Meredith C, Greenawalt, Danielle M, Griffin, Paula, Ding, Jinghong, Newman, Anne B, Tylavsky, Fran, Miljkovic, Iva, Kritchevsky, Stephen B, Launer, Lenore, Garcia, Melissa, Eiriksdottir, Gudny, Carr, J Jeffrey, Gudnason, Vilmunder, Harris, Tamara B, Cupples, L Adrienne, Borecki, Ingrid B
Published in PLoS genetics

Comparative performances of machine learning methods for classifying Crohn Disease patients using genome-wide genotyping data

by Romagnoni, Alberto, Jégou, Simon, Van Steen, Kristel, Wainrib, Gilles, Hugot, Jean-Pierre
Published in Scientific reports

Mining the human phenome using allelic scores that index biological intermediates

by Evans, David M, Brion, Marie Jo A, Paternoster, Lavinia, Kemp, John P, McMahon, George, Munafò, Marcus, Whitfield, John B, Medland, Sarah E, Montgomery, Grant W, Timpson, Nicholas J, St Pourcain, Beate, Lawlor, Debbie A, Martin, Nicholas G, Dehghan, Abbas, Hirschhorn, Joel, Smith, George Davey
Published in PLoS genetics

High-efficiency RNA-based reprogramming of human primary fibroblasts

by Kogut, Igor, McCarthy, Sandra M, Pavlova, Maryna, Astling, David P, Chen, Xiaomi, Jakimenko, Ana, Jones, Kenneth L, Getahun, Andrew, Cambier, John C, Pasmooij, Anna M G, Jonkman, Marcel F, Roop, Dennis R, Bilousova, Ganna
Published in Nature communications

Differential methylation of the TRPA1 promoter in pain sensitivity

by Bell, J T, Loomis, A K, Butcher, L M, Gao, F, Zhang, B, Hyde, C L, Sun, J, Wu, H, Ward, K, Harris, J, Scollen, S, Davies, M N, Schalkwyk, L C, Mill, J, Williams, F M K, Li, N, Deloukas, P, Beck, S, McMahon, S B, Wang, J, John, S L, Spector, T D
Published in Nature communications

LTR_STRUC: a novel search and identification program for LTR retrotransposons

by McCarthy, Eugene M., McDonald, John F.
Published in Bioinformatics

Whole-genome sequencing of bladder cancers reveals somatic CDKN1A mutations and clinicopathological associations with mutation burden

by Cazier, J-B, Rao, S R, McLean, C M, Walker, A K, Walker, A L, Wright, B J, Jaeger, E E M, Kartsonaki, C, Marsden, L, Yau, C, Camps, C, Kaisaki, P, Taylor, J, Catto, J W, Tomlinson, I P M, Kiltie, A E, Hamdy, F C
Published in Nature communications

Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes: A Mendelian Randomisation Analysis

by Lotta, Luca A, Scott, Robert A, Sharp, Stephen J, Burgess, Stephen, Luan, Jian'an, Tillin, Therese, Schmidt, Amand F, Imamura, Fumiaki, Stewart, Isobel D, Perry, John R B, Marney, Luke, Koulman, Albert, Karoly, Edward D, Forouhi, Nita G, Sjögren, Rasmus J O, Näslund, Erik, Zierath, Juleen R, Krook, Anna, Savage, David B, Griffin, Julian L, Chaturvedi, Nishi, Hingorani, Aroon D, Khaw, Kay-Tee, Barroso, Inês, McCarthy, Mark I, O'Rahilly, Stephen, Wareham, Nicholas J, Langenberg, Claudia
Published in PLoS medicine

Ribosome biogenesis and degradation regulate translational capacity during muscle disuse and reloading

by Figueiredo, Vandré C., D'Souza, Randall F., Van Pelt, Douglas W., Lawrence, Marcus M., Zeng, Nina, Markworth, James F., Poppitt, Sally D., Miller, Benjamin F., Mitchell, Cameron J., McCarthy, John J., Dupont‐Versteegden, Esther E., Cameron‐Smith, David
Published in Journal of cachexia, sarcopenia and muscle

RSPO3 impacts body fat distribution and regulates adipose cell biology in vitro

by Loh, Nellie Y, Minchin, James E N, Pinnick, Katherine E, Verma, Manu, Todorčević, Marijana, Denton, Nathan, Moustafa, Julia El-Sayed, Kemp, John P, Gregson, Celia L, Evans, David M, Neville, Matt J, Small, Kerrin S, McCarthy, Mark I, Mahajan, Anubha, Rawls, John F, Karpe, Fredrik, Christodoulides, Constantinos
Published in Nature communications

Genomic variability of monkeypox virus among humans, Democratic Republic of the Congo

by Kugelman, Jeffrey R, Johnston, Sara C, Mulembakani, Prime M, Kisalu, Neville, Lee, Michael S, Koroleva, Galina, McCarthy, Sarah E, Gestole, Marie C, Wolfe, Nathan D, Fair, Joseph N, Schneider, Bradley S, Wright, Linda L, Huggins, John, Whitehouse, Chris A, Wemakoy, Emile Okitolonda, Muyembe-Tamfum, Jean Jacques, Hensley, Lisa E, Palacios, Gustavo F, Rimoin, Anne W
Published in Emerging infectious diseases

Genomic profiling of messenger RNAs and microRNAs reveals potential mechanisms of TWEAK-induced skeletal muscle wasting in mice

by Panguluri, Siva K, Bhatnagar, Shephali, Kumar, Akhilesh, McCarthy, John J, Srivastava, Apurva K, Cooper, Nigel G, Lundy, Robert F, Kumar, Ashok
Published in PloS one

Genital microbiota of women using a 90 day tenofovir or tenofovir and levonorgestrel intravaginal ring in a placebo controlled randomized safety trial in Kenya

by Dabee, Smritee, Mugo, Nelly, Mudhune, Victor, McLellan-Lemal, Eleanor, Peacock, Sue, O'Connor, Siobhan, Njoroge, Betty, Nyagol, Beatrice, Thurman, Andrea R, Ouma, Eunice, Ridzon, Renee, Wiener, Jeffrey, Haugen, Harald S, Gasper, Melanie, Feng, Colin, Allen, Shannon A, Doncel, Gustavo F, Jaspan, Heather B, Heffron, Renee
Published in Scientific reports